| Identification | Back Directory | [Name]
(4R)-4-[(3S,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid | [CAS]
2276-93-9 | [Synonyms]
Isoallolithocholic acid
Alloisolithocholic Acid
5a-CHOLANIC ACID-3-β-OL
5a-Cholanic Acid-3-ol-d2
5α-Cholanic Acid-3β-ol D2
Isoallolithocholic Acid (5-alfa-Cholanic Acid-3-beta-ol)
(R)-4-((3S,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
(4R)-4-[(3S,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid | [Molecular Formula]
C24H40O3 | [MOL File]
2276-93-9.mol | [Molecular Weight]
376.57 |
| Chemical Properties | Back Directory | [Melting point ]
>170°C (dec.) | [Boiling point ]
511.0±23.0 °C(Predicted) | [density ]
1.073±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C, Inert atmosphere | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.76±0.10(Predicted) | [color ]
White to Off-White | [InChIKey]
SMEROWZSTRWXGI-XBESLWPFSA-N | [SMILES]
[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)[C@@]3([H])CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC(O)=O |
| Hazard Information | Back Directory | [Uses]
Isoallolithocholic Acid is used as a steroid compound as T regulatory lymphocyte modulators and uses for treatment of inflammatory or autoimmune disorders. | [Definition]
ChEBI: Isoallolithocholic acid is a bile acid. | [in vivo]
Isoallolithocholic acid (0.03%; in diet; 7 days) enhances Treg cells in B6 mice[1]. | Animal Model: | Segmented filamentous bacteria (SFB)-colonized Jax-B6 mice[1] | | Dosage: | 0.03% (w/w) | | Administration: | In diet, 7 days | | Result: | Was insufficient to enhance Treg percentages both at steady state and following anti-CD3 treatment alone. Significantly enhanced the Treg population in mice treated with anti-CD3 compared to control diet in combination with 0.3% (w/w) 3-oxolithocholic acid (3-oxoLCA). Reduced the number of CD45.1+ T effector cells. |
| [storage]
Store at -20°C |
|
| Company Name: |
Alfa Chemistry
|
| Tel: |
1-516-6625404 |
| Website: |
https://www.alfa-chemistry.com |
| Company Name: |
Rhawn Reagent
|
| Tel: |
400-400-1332688 18019345275 |
| Website: |
http://www.rhawn.cn |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|