| Identification | Back Directory | [Name]
proquazone | [CAS]
22760-18-5 | [Synonyms]
43-715
Biarsan
Biarison
proquazone
SaH-43-715
Sandoz-43-715
7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one
7-Methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone
2(1H)-Quinazolinone, 7-methyl-1-(1-methylethyl)-4-phenyl- | [EINECS(EC#)]
245-203-7 | [Molecular Formula]
C18H18N2O | [MDL Number]
MFCD00866169 | [MOL File]
22760-18-5.mol | [Molecular Weight]
278.35 |
| Chemical Properties | Back Directory | [Melting point ]
137-138° | [Boiling point ]
436.12°C (rough estimate) | [density ]
1.1707 (rough estimate) | [refractive index ]
1.5700 (estimate) | [pka]
0.74±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Anti-inflammatory. | [Uses]
Proquazone is a non-steroidal anti-inflammatory drug. | [Definition]
ChEBI: Proquazone is a member of pyrimidines. | [Brand name]
Arthrex (Novartis). | [Clinical Use]
Proquazone has been used successfully to
treat rheumatoid polyarthritis. At 900 mg/d it
is comparable in effect to 150 mg/d of indomethacin. Gastrointestinal disturbances are
the principal adverse effects observed with its
use. | [Synthesis]
Synthesis: proquazone is prepared by the
alkylation of 2-amino-4-methylbenzophenone
with 2-iodopropane in the presence of
sodium carbonate to give 4-methyl-2-[(1-
methylethyl)amino]benzophenone, which is
condensed with urethane in the presence of
zinc chloride at 190 C.
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