| Identification | Back Directory | [Name]
(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydro-thieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide | [CAS]
227609-66-7 | [Synonyms]
A-278637
A-278637 >=98%
(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydro-thieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide
Thieno[3,2-b]quinolin-8(4H)-one, 9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydro-, 1,1-dioxide, (9S)- | [Molecular Formula]
C17H15BrFNO3S | [MOL File]
227609-66-7.mol | [Molecular Weight]
412.27 |
| Chemical Properties | Back Directory | [Boiling point ]
617.4±55.0 °C(Predicted) | [density ]
1.70±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
-2.28±0.40(Predicted) | [color ]
white to beige | [Optical Rotation]
[α]/D -44 to -54°, c = 0.1 in acetonitrile |
| Hazard Information | Back Directory | [Biological Activity]
A-278637 is a selective opener of ATP-sensitive K (KATP) channels (EC50 = 102 nM) th at blocks contraction of bladder smooth muscle in both in vivo and in vitro assays. A-278637 is 15-fold more selective than nifedipine for bladder compared other smooth muscle KATP channelsand displays reduced effects on mean arterial pressure compared to other channel openers. |
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| Company Name: |
Energy Chemical
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| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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