| Identification | Back Directory | [Name]
Glycinamide, N2-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-glutaminyl-L-valyl-L-prolyl-L-tryptophyl-L-α-glutamyl-L-α-glutamyl-L-prolyl-L-tyrosyl-L-tyrosyl-L-valyl-L-valyl-L-lysyl-L-lysyl-L-seryl-L-serylglycyl- | [CAS]
2276787-79-0 | [Synonyms]
Bevonescein
Glycinamide, N2-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-glutaminyl-L-valyl-L-prolyl-L-tryptophyl-L-α-glutamyl-L-α-glutamyl-L-prolyl-L-tyrosyl-L-tyrosyl-L-valyl-L-valyl-L-lysyl-L-lysyl-L-seryl-L-serylglycyl- | [Molecular Formula]
C112H144N22O32 | [MOL File]
2276787-79-0.mol | [Molecular Weight]
2310.51 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.44±0.10(Predicted) | [color ]
Yellow to orange | [Sequence]
(5-FAM)-Gln-Val-Pro-Trp-Glu-Glu-Pro-Tyr-Tyr-Val-Val-Lys-Lys-Ser-Ser-Gly-Gly-(C-terminal amide) |
| Hazard Information | Back Directory | [Uses]
Bevonescein (ALM-488) is a novel, intravenously-administrated fluorescein-conjugated peptide that binds nerve-associated connective tissue, labels peripheral nerves under real-time fluorescence imaging (FL) in living mice and human ex vivo nerve tissue. Bevonescein is a peptide-linked tracer which fluorescently labeled both intact and degenerated nerves[1][2]. | [in vivo]
Bevonescein (ALM-488; 900 nmol; IV; underwent a 90-minute observation period) improves nerve identification for intact, degenerated, and partially regenerated nerves by vivo realtime fluorescence imaging (FL) in female SKH‐1 hairless, wild‐type, ~25 g mice[1]. | [References]
[1] Kayva L Crawford, et al. Identification of Degenerated Murine Facial Nerves With Fluorescence Labeling After Transection Injury. Otolaryngol Head Neck Surg. 2023 Aug;169(2):234-242. DOI:10.1002/ohn.262
[2] Feredun Azari, et al. Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings. J Biomed Opt. 2021 May;26(5):050901. Feredun Azari, et al. Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings. J Biomed Opt. 2021 May;26(5):050901. DOI:10.1117/1.JBO.26.5.050901 |
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YantaiBio
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Fuan Bio
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15002819872 |
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