| Identification | Back Directory | [Name]
Urea, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N'-[2-[(5-hydroxy-1H-indol-2-yl)carbonyl]-5-benzofuranyl]- | [CAS]
2278278-04-7 | [Synonyms]
FLT3/ITD-IN-4
Urea, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N'-[2-[(5-hydroxy-1H-indol-2-yl)carbonyl]-5-benzofuranyl]- | [Molecular Formula]
C25H22N4O5 | [MOL File]
2278278-04-7.mol | [Molecular Weight]
458.47 |
| Hazard Information | Back Directory | [Uses]
FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC50 of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research[1]. | [IC 50]
FLT3-ITD: 2.3 nM (IC50); FLT3 D835Y: 4.84 nM (IC50); RET: 277 nM (EC50); FLT3: 443 nM (EC50); ZAK/MLTK: 1069 nM (EC50); CDK16/Cyclin Y: 1768 nM (EC50); DDR2: 2494 nM (EC50); EPHA7: 3255 nM (EC50); NTRK1: 3857 nM (EC50); MAP4K4: 5737 nM (EC50) | [References]
[1] Sellmer A, et al. A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia. Eur J Med Chem. 2020 May 1;193:112232. DOI:10.1016/j.ejmech.2020.112232 |
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