| Identification | Back Directory | [Name]
TANDUTINIB | [CAS]
228266-40-8 | [Synonyms]
CS-1371
Hti 286
Spa 110
Taltobulin
Unii-J6D6912bxs
HTI-286;SPA-110
Taltobulin (HTI-286)
HTI-286 hydrochloride
SPA-110 hydrochloride
HTI-286 HYDROCHLORIDE;SPA-110 HYDROCHLORIDE
N,β,β-Trimethyl-L-phenylalanyl-N-[(3S,4E)-5-carboxy-2-methyl-4-hexen-3-yl]-N,3-dimethyl-L-valinamide
L-Valinamide, N,β,β-trimethyl-L-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-buten-1-yl]-N,3-dimethyl-
N,beta,beta-Trimethyl-L-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-butenyl]-N,3-dimethyl-L-valinamide
L-Valinamide, N,beta,beta-trimethyl-L-phenylalanyl-N-((1S,2E)-3-carboxy-1-(1-methylethyl)-2-butenyl)-N,3-dimethyl- | [Molecular Formula]
C27H43N3O4 | [MDL Number]
MFCD07772353 | [MOL File]
228266-40-8.mol | [Molecular Weight]
473.66 |
| Chemical Properties | Back Directory | [Melting point ]
135-137 ºC | [Boiling point ]
662.4±55.0 °C(Predicted) | [density ]
1.063 | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO: 40 mg/ml | [form ]
A solid | [pka]
4.68±0.19(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Treatment of solid tumors. | [in vivo]
Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) in athymic nu/nu female mice[1].
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Taltobulin (HTI-286; 3 mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu female mice with Lox melanoma xenografts and KB-3-1 epidermoid xenograft model, respectively[1]. | Animal Model: | Athymic nu/nu female mice with Lox melanoma model (5-6 weeks of age)[1] | | Dosage: | 1.6 mg/kg | | Administration: | Administered i.v.;for 35 days | | Result: | Growth of Lox tumors was inhibited by 96-98% on day 12 compared with vehicle-treated controls.
Growth of KB-8-5 tumors was inhibited by 84% on day 14 compared with vehicle-treated controls.
Growth of MX-1W tumors was inhibited by 97% compared with vehicle-treated controls.
Growth of DLD-1 and HCT-15 tumors was inhibited by 80 and 66%, respectively. |
| [IC 50]
Traditional Cytotoxic Agents |
|
| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Abydos Scientific
|
| Telephone: |
18936879710 18851749494 |
| Website: |
www.abydoscientific.com/index.html |
| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
| Company Name: |
Nextpeptide Inc
|
| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
|