| Hazard Information | Back Directory | [Uses]
(Arg)9 (Nona-L-arginine) TFA is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 TFA has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model[1][2]. | [in vivo]
(Arg)9 (Nona-L-arginine; 1?μM/kg (600? μL); i.v.; once, for 30min; male Sprague–Dawley ratspermanent middle cerebral artery stroke model) TFA shows neuroprotective effects and reduces infarct volume[2]. | Animal Model: | Male Sprague–Dawley rats (270 to 320?g) permanent middle cerebral artery stroke model[2] | | Dosage: | 1 μM/kg (600? μL) | | Administration: | Intravenous injection; once, over 5 minutes | | Result: | Reduced significantiy 20% in infarct volume. |
| [References]
[1] Meloni BP, et, al. The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014 Mar;34(2):173-81. DOI:10.1007/s10571-013-9999-3
[2] Meloni BP, et, al. Poly-arginine and arginine-rich peptides are neuroprotective in stroke models. J Cereb Blood Flow Metab. 2015 Jun;35(6):993-1004. DOI:10.1038/jcbfm.2015.11 |
|
|