| Identification | Back Directory | [Name]
N-Acetylpuromycin | [CAS]
22852-13-7 | [Synonyms]
N-Acetylpuromycin
3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine
Adenosine, 3'-[[(2S)-2-(acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl- | [Molecular Formula]
C24H31N7O6 | [MDL Number]
MFCD30182346 | [MOL File]
22852-13-7.mol | [Molecular Weight]
513.55 |
| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 70 mg/ml) or in DMF (up to 55 mg/ml) | [form ]
solid | [pka]
12.98±0.70(Predicted) | [color ]
White | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 2 months. |
| Hazard Information | Back Directory | [Description]
N-Acetylpuromycin is a non-ribotoxic form of the antibiotic puromycin that is formed in puromycin-resistant S. alboniger that endogenously express puromycin-acetyltransferase. In AD293(Pr) cells that express puromycin-N-acetyltransferase, the enzyme responsible for the biosynthesis of N-acetylpuromycin, puromycin application induces downregulation of the negative regulators of TGF-β signalling SnoN and Ski without activating MAPK or inhibition of protein synthesis. | [Uses]
N-Acetylpurinomycin downregulates SnoN and Ski protein expression and promotes TGF-β signaling, independently of MAPK activation. | [storage]
Store at -20°C | [References]
1) Hernandez-Damian?et al. (2013),?Downregulation of SnoN oncoprotein induced by antibiotics anisomycin and puromycin positively regulates transforming growth factor-β signals; Biochim. Biophys. Acta,?1830?5049 |
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