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2285346-31-6

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2285346-31-6 Structure

2285346-31-6 Structure
IdentificationBack Directory
[Name]

RTS-V5
[CAS]

2285346-31-6
[Synonyms]

RTS-V5
[Molecular Formula]

C27H35N5O6
[MDL Number]

MFCD34469268
[MOL File]

2285346-31-6.mol
[Molecular Weight]

525.61
Chemical PropertiesBack Directory
[density ]

1.226±0.06 g/cm3(Predicted)
[pka]

8.51±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

RTS-V5 is a dual HDAC/proteasome inhibitor with IC50s of 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively.
[References]

[1] Bhatia S, et al. Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. J Med Chem. 2018 Nov 21;61(22):10299-10309. DOI:10.1021/acs.jmedchem.8b01487
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