| Identification | Back Directory | [Name]
2,8-Diazaspiro[4.5]decane, 8-(6,7-dimethoxy-4-quinazolinyl)- | [CAS]
2289736-54-3 | [Synonyms]
Enpp-1-IN-17
2,8-Diazaspiro[4.5]decane, 8-(6,7-dimethoxy-4-quinazolinyl)- | [Molecular Formula]
C18H24N4O2 | [MOL File]
2289736-54-3.mol | [Molecular Weight]
328.41 |
| Hazard Information | Back Directory | [Uses]
Enpp-1-IN-17 (example 274) is a potent ENPP1 inhibitor, with the inhibition constants (Ki values) toward cGAMP and ATP hydrolysis of 100 nM-1 μM and > 1 μM, respectively. The selectivity ratio for inhibition of cGAMP hydrolysis versus ATP hydrolysis is >6.4[1]. | [References]
[1] William Michael Gallatin, et al. Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitors and uses thereof. Patent, WO2019046778A1. |
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