| Identification | Back Directory | [Name]
R 892 | [CAS]
229030-05-1 | [Synonyms]
R 892
L-Isoleucine, N2-acetyl-L-lysyl-L-arginyl-L-prolyl-L-prolylglycyl-N-methyl-L-phenylalanyl-L-seryl-3-(2-naphthalenyl)-D-alanyl- | [Molecular Formula]
C58H83N13O12 | [MDL Number]
MFCD12912473 | [MOL File]
229030-05-1.mol | [Molecular Weight]
1154.36 |
| Hazard Information | Back Directory | [Description]
Potent and selective bradykinin B1receptor antagonist (ID50values are 8 and > 600 nM at B1and B2receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activityin vivo. | [Uses]
R892 is a selective and efficient bradyKinin B1 receptor antagonist with significant antagonistic activity. The pA2 values of R892 in human and rabbit B1 receptors are 8.8 and 8.6 respectively, indicating its strong anti-activity at these receptors. R892 exhibits selectivity with ID50 values of 2.8 nM and >600 nM for B1 and B2 receptors, respectively, and has no endogenous agonist activity. R892 is resistant to aminopeptidase and kininase II (ACE) degradation and exhibits metabolic stability[1]. | [storage]
Desiccate at -20°C | [References]
[1] Kinin B1 receptor antagonists containing alpha-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities |
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| Company Name: |
Combio (Suzhou) Ltd.
|
| Telephone: |
17751201929; 17751201929 |
| Website: |
http://www.combiosz.com/ |
| Company Name: |
Fuan Bio
|
| Telephone: |
15002819872 |
| Website: |
fuanbio.com |
|