| Identification | Back Directory | [Name]
Bractoppin | [CAS]
2290527-07-8 | [Synonyms]
Bractoppin
Methanone, [4-[(2-fluorophenyl)methyl]-1-piperazinyl](2-phenyl-1H-benzimidazol-6-yl)-
DNA break,Bractoppin,phosphopeptide,inhibit,DNA/RNA Synthesis,DNA damage,RAD51,G2 arrest,Inhibitor,BRCA1 tBRCT | [Molecular Formula]
C25H23FN4O | [MDL Number]
MFCD33402156 | [MOL File]
2290527-07-8.mol | [Molecular Weight]
414.47 |
| Chemical Properties | Back Directory | [Boiling point ]
625.7±65.0 °C(Predicted) | [density ]
1.299±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (603.18 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.70±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response[1]. | [storage]
Store at -20°C | [References]
[1] Jayaprakash Periasamy, et al. Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling. Cell Chem Biol. 2018 Jun 21;25(6):677-690.e12. DOI:10.1016/j.chembiol.2018.02.012 |
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| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|