| Identification | Back Directory | [Name]
Phosphonic acid, P-[2-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]ethyl]- | [CAS]
2298390-71-1 | [Synonyms]
(2-(1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl)ethyl)phosphonic acid
Phosphonic acid, P-[2-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]ethyl]- | [Molecular Formula]
C17H24N3O5P | [MOL File]
2298390-71-1.mol | [Molecular Weight]
381.36 |
| Chemical Properties | Back Directory | [Boiling point ]
614.9±65.0 °C(Predicted) | [density ]
1.328±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
2.58±0.10(Predicted) | [color ]
white to beige | [InChI]
1S/C17H24N3O5P/c1-24-15-9-13-14(10-16(15)25-2)18-11-19-17(13)20-6-3-12(4-7-20)5-8-26(21,22)23/h9-12H,3-8H2,1-2H3,(H2,21,22,23) | [InChIKey]
SNLWMWQNJTVWKD-UHFFFAOYSA-N | [SMILES]
O=P(O)(O)CCC(CC1)CCN1C2=NC=NC3=C2C=C(OC)C(OC)=C3 |
| Hazard Information | Back Directory | [Biological Activity]
STF-1084 (ENPP1 inhibitor Compound 15) Is a cell-impermeablepotentselectivestable and nontoxic competitive inhibitor of ENPP1 (ectonucleotide pyrophosphatase phosphodiesterase 1) th at inhibit degradation of extracellular cGAMP under physiological conditions. STF-1084 had no effect on intracellular cGAMP. STF-1084 synergized with IR to significantly delay tumor progression in three triple-negative breast cancer cell lines 4T1-luc mice model. |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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