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Olezarsen sodium is an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-III (apoC-III) production, in lowering triglyceride levels in patients at high risk for or with established cardiovascular disease. | [IC 50]
apoC3 | [References]
[1] Tardif JC, Karwatowska-Prokopczuk E, Amour ES, et al. Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk.?Eur Heart J. 2022;43(14):1401-1412. DOI:10.1093/eurheartj/ehab820
[2] Karwatowska-Prokopczuk E, Tardif JC, Gaudet D, et al. Effect of olezarsen targeting APOC-III on lipoprotein size and particle number measured by NMR in patients with hypertriglyceridemia.?J Clin Lipidol. 2022;16(5):617-625. DOI:10.1016/j.jacl.2022.06.005 |
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