| Identification | Back Directory | [Name]
2-(4-PIPERIDYL)-2-PROPANOL | [CAS]
22990-34-7 | [Synonyms]
2-(4-PIPERIDYL)-2-PROPANOL
2-(4-Piperidinyl)-2-propanol
2-(Piperidin-4-yl)propan-2-ol
2-(4-PIPERIDYL)ISOPROPYL ALCOHOL
a,a-DiMethyl-4-piperidineMethanol
4-PIPERIDINEMETHANOL, ALPHA,ALPHA-DIMETHYL-
2-piperidin-4-ylpropan-2-ol(SALTDATA: FREE)
2-(4-Piperidyl)isopropyl Alcohol
2-(Piperidin-4-yl)propan-2-ol | [Molecular Formula]
C8H17NO | [MDL Number]
MFCD06797159 | [MOL File]
22990-34-7.mol | [Molecular Weight]
143.23 |
| Chemical Properties | Back Directory | [Melting point ]
136°C | [Boiling point ]
140-142 °C(Press: 25 Torr) | [density ]
0.956±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [pka]
15.08±0.29(Predicted) | [Appearance]
Off-white to yellow Solid | [InChI]
InChI=1S/C8H17NO/c1-8(2,10)7-3-5-9-6-4-7/h7,9-10H,3-6H2,1-2H3 | [InChIKey]
IIXYTWTZMGUQPT-UHFFFAOYSA-N | [SMILES]
C(C1CCNCC1)(O)(C)C | [CAS DataBase Reference]
22990-34-7 |
| Hazard Information | Back Directory | [Uses]
2-(Piperidin-4-yl)propan-2-ol is a useful research chemical. | [Synthesis]
Benzyl 4-(1-hydroxy-1-methylethyl)piperidine-1-carboxylate (1.786 g, 6.44 mmol) was used as starting material and dissolved in methanol (100 ml) under nitrogen protection. A 10% palladium-carbon catalyst (50% wet, 1.37 g) was added, followed by replacement of the gas in the reaction system with hydrogen at atmospheric pressure. The reaction mixture was stirred at room temperature for overnight reaction. Upon completion of the reaction, the hydrogen in the reaction system was replaced with nitrogen, then the catalyst was removed by filtration and washed with methanol. The filtrate and washings were combined and the solvent was removed by distillation. Finally, the residue was dried under reduced pressure to afford the target product 2-(4-piperidinyl)-2-propanol (922 mg, 6.44 mmol, quantitative yield) as light gray crystals. The product was characterized by 1H-NMR (CDCl3), δ (ppm): 1.18 (6H, s), 1.26-1.42 (3H, m), 1.74-1.80 (2H, m), 2.57-2.64 (2H, m), 3.14-3.22 (2H, m), 3.48 (1H, s). | [References]
[1] Patent: EP1522540, 2005, A1. Location in patent: Page/Page column 64
[2] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 14, p. 1935 - 1940 |
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