| Identification | Back Directory | [Name]
1H-Pyrazole-1-propanol, 4-[3-(2-chloro-6-fluorophenyl)-4-(2-pyrimidinyl)-5-isoxazolyl]-α,α-dimethyl-5-(trifluoromethyl)- | [CAS]
2299252-72-3 | [Synonyms]
Izumerogant
1H-Pyrazole-1-propanol, 4-[3-(2-chloro-6-fluorophenyl)-4-(2-pyrimidinyl)-5-isoxazolyl]-α,α-dimethyl-5-(trifluoromethyl)- | [Molecular Formula]
C22H18ClF4N5O2 | [MOL File]
2299252-72-3.mol | [Molecular Weight]
495.86 |
| Chemical Properties | Back Directory | [Boiling point ]
572.1±50.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.95±0.29(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
Izumerogant (IMU-935) is an inverse agonist of retinoid-related orphan receptor-gamma (RORγ). Izumerogant (compound 123) also potently inhibits IL-17A, IL-17F and IFN-γ activity with IC50s <50 nM[1][2]. | [References]
[1] F Jakob, et al. Isoxazole-pyrazole derivatives and related compounds as IL-17 and IFN-γ inhibitors for treating autoimmune diseases and chronic inflammation: World Intellectual Property Organization, WO2019048541. 2019-03-14.
[2] WHO Drug Information-World Health Organization (WHO). |
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