| Identification | Back Directory | [Name]
H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH | [CAS]
229961-08-4 | [Synonyms]
APELIN 12
RPRLSHKGPMPF
Apelin-12,(Des-Gln1)-Apelin-13
APELIN-12 (HUMAN, BOVINE, MOUSE, RAT)
ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
PREPROAPELIN (66-77) (HUMAN, BOVINE, MOUSE, RAT)
(DES-GLN1)-APELIN-13 (HUMAN, BOVINE, MOUSE, RAT)
APELIN PRECURSOR (66-77) (HUMAN, BOVINE, MOUSE, RAT)
H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
Apelin-12 (human, bovine, mouse, rat) H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
L-Phenylalanine, L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-
(Des-Gln1)-Apelin-13 (huMan, bovine, Mouse, rat), Apelin Precursor (66-77) (huMan, bovine, Mouse, rat), Preproapelin (66-77) (huMan, bovine, Mouse, rat)
Apelin-12 (huMan, bovine, Mouse, rat)
(Des-Gln1)-Apelin-13 (huMan, bovine, Mouse, rat), Apelin Precursor (66-77) (huMan, bovine, Mouse, rat), Preproapelin (66-77) (huMan, bovine, Mouse, rat)
Apelin-12 (human, bovine, mouse, rat)?/(Des-Gln1)-Apelin-13 (human, bovine, mouse, rat), Preproapelin (66-77) (human, bovine, mouse, rat), Apelin Precursor (66-77) (human, bovine, mouse, rat) | [Molecular Formula]
C64H103N21O14S | [MDL Number]
MFCD05664679 | [MOL File]
229961-08-4.mol | [Molecular Weight]
1422.7 |
| Chemical Properties | Back Directory | [RTECS ]
CD7310000 | [storage temp. ]
-15°C | [form ]
Lyophilized powder | [color ]
White to off-white | [Sequence]
H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH | [InChIKey]
KIODTAJAFBDDGP-TZIGXLGFSA-N |
| Hazard Information | Back Directory | [Uses]
Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect[1][2][3]. | [IC 50]
HIV-1 | [References]
[1] Pisarenko OI, et al. Effects of structural analogues of apelin-12 in acute myocardial infarction in rats. J Pharmacol Pharmacother. 2013;4(3):198-203. DOI:10.4103/0976-500X.114600
[2] Pisarenko OI, et al. Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion. Mol Cell Biochem. 2014;391(1-2):241-250. DOI:10.1007/s11010-014-2008-4
[3] Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895. Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895. DOI:10.26355/eurrev_201806_15273
[4] Ohno S, et al. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs. Regul Pept. 2012;174(1-3):71-78. DOI:10.1016/j.regpep.2011.12.002 |
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