229961-08-4

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229961-08-4 Structure

Identification	Back Directory
[Name] H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
[CAS] 229961-08-4
[Synonyms] APELIN 12 RPRLSHKGPMPF Apelin-12,(Des-Gln1)-Apelin-13 APELIN-12 (HUMAN, BOVINE, MOUSE, RAT) ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE PREPROAPELIN (66-77) (HUMAN, BOVINE, MOUSE, RAT) (DES-GLN1)-APELIN-13 (HUMAN, BOVINE, MOUSE, RAT) APELIN PRECURSOR (66-77) (HUMAN, BOVINE, MOUSE, RAT) H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH Apelin-12 (human, bovine, mouse, rat) H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH L-Phenylalanine, L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl- (Des-Gln1)-Apelin-13 (huMan, bovine, Mouse, rat), Apelin Precursor (66-77) (huMan, bovine, Mouse, rat), Preproapelin (66-77) (huMan, bovine, Mouse, rat) Apelin-12 (huMan, bovine, Mouse, rat) (Des-Gln1)-Apelin-13 (huMan, bovine, Mouse, rat), Apelin Precursor (66-77) (huMan, bovine, Mouse, rat), Preproapelin (66-77) (huMan, bovine, Mouse, rat) Apelin-12 (human, bovine, mouse, rat)?/(Des-Gln1)-Apelin-13 (human, bovine, mouse, rat), Preproapelin (66-77) (human, bovine, mouse, rat), Apelin Precursor (66-77) (human, bovine, mouse, rat)
[Molecular Formula] C64H103N21O14S
[MDL Number] MFCD05664679
[MOL File] 229961-08-4.mol
[Molecular Weight] 1422.7

Chemical Properties	Back Directory
[RTECS ] CD7310000
[storage temp. ] -15°C
[form ] Lyophilized powder
[color ] White to off-white
[Sequence] H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH

Hazard Information	Back Directory
[Uses] Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect[1][2][3].
[IC 50] HIV-1
[References] [1] Pisarenko OI, et al. Effects of structural analogues of apelin-12 in acute myocardial infarction in rats. J Pharmacol Pharmacother. 2013;4(3):198-203. DOI:10.4103/0976-500X.114600 [2] Pisarenko OI, et al. Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion. Mol Cell Biochem. 2014;391(1-2):241-250. DOI:10.1007/s11010-014-2008-4 [3] Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895. Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895. DOI:10.26355/eurrev_201806_15273 [4] Ohno S, et al. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs. Regul Pept. 2012;174(1-3):71-78. DOI:10.1016/j.regpep.2011.12.002

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