| Identification | Back Directory | [Name]
1-phenyl-4-piperidin-1-ylpyrazolo[3,4-d]pyrimidine | [CAS]
23000-46-6 | [Synonyms]
BUR1
BMP upregulator 1
BMP upregulator-1
1-phenyl-4-piperidin-1-ylpyrazolo[3,4-d]pyrimidine
1-{1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine | [Molecular Formula]
C16H17N5 | [MDL Number]
MFCD00420078 | [MOL File]
23000-46-6.mol | [Molecular Weight]
279.34 |
| Chemical Properties | Back Directory | [Boiling point ]
416.3±38.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.80±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
BUR1 is a selective BMP upregulator. It acts by increasing expression of Inhibitor of DNA binding 1 (Id1) and inducing BMP2 and PTGS2 expression. | [Uses]
BUR1 is a BMP upregulator (EC50: 98 nM) and activates BMPRII signalling. BUR1 induces BMP2 and PTGS2 expression. BUR1 reversed pulmonary arterial pressure in Monocrotaline (HY-N0750) induced rats[1]. | [in vivo]
BUR1 (4.5 mg/day, i.g., 3 weeks) reverses MCT-induced pulmonary arterial pressure and right ventricular systolic pressure in rats[1].
| [References]
[1] Xing Y, et al. A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels. Eur Respir J. 2018 Apr 4;51(4):1702229. DOI:10.1183/13993003.02229-2017 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
OTAVA chemicals
|
| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
|