| Identification | Back Directory | [Name]
4-(4-acryloyl-3,5-dimethylpiperazin-1-yl)-7-(2-amino-6-fluorophenyl)-6-chloro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one | [CAS]
2300967-40-0 | [Synonyms]
KRAS G12C inhibitor 61 | [Molecular Formula]
C31H33ClFN7O2 | [MOL File]
2300967-40-0.mol | [Molecular Weight]
590.091 |
| Hazard Information | Back Directory | [Uses]
KRAS G12C inhibitor 61 (Example 3) inhibits phospho-ERK 1/2 in MIA PaCa-2 cells with an IC50 value of 9 nM. KRAS G12C inhibitor 61 can be used for research of pancreatic, colorectal, and lung cancers[1]. | [IC 50]
K-Ras WT | [References]
[1] Brian Alan Lanman, et al. Inhibitors of kras g12c and methods of using the same. Patent. WO2019051291. |
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