| Identification | Back Directory | [Name]
4(3H)-Quinazolinone, 7-chloro-6-fluoro-3-[2-oxo-3-(2S)-2-piperidinylpropyl]- | [CAS]
2304448-00-6 | [Synonyms]
Antibacterial agent 124
4(3H)-Quinazolinone, 7-chloro-6-fluoro-3-[2-oxo-3-(2S)-2-piperidinylpropyl]- | [Molecular Formula]
C16H17ClFN3O2 | [MOL File]
2304448-00-6.mol | [Molecular Weight]
337.78 |
| Hazard Information | Back Directory | [Uses]
Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC50 of 0.18 μM against Staphylococcus aureus ProRS (SaProRS)[1]. | [References]
[1] Cheng B, et al. Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. J Med Chem. 2022 Nov 17. DOI:10.1021/acs.jmedchem.2c01496 |
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