| Identification | Back Directory | [Name]
7-(((1R,2S)-2-aminocyclohexyl)amino)-4-oxo-5-(m-tolylamino)-3,4-dihydropyrido[3,4-d]pyridazine-8-carbonitrile | [CAS]
2304654-43-9 | [Synonyms]
DS21360717
DS21360717,DS-21360717
7-(((1R,2S)-2-aminocyclohexyl)amino)-4-oxo-5-(m-tolylamino)-3,4-dihydropyrido[3,4-d]pyridazine-8-carbonitrile
Pyrido[3,4-d]pyridazine-8-carbonitrile, 7-[[(1R,2S)-2-aminocyclohexyl]amino]-3,4-dihydro-5-[(3-methylphenyl)amino]-4-oxo- | [Molecular Formula]
C21H23N7O | [MDL Number]
MFCD32067958 | [MOL File]
2304654-43-9.mol | [Molecular Weight]
389.45 |
| Chemical Properties | Back Directory | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.48±0.20(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
DS21360717 is a potent and orally active FER tyrosine kinase inhibitor, with an IC50 of 0.49 nM. Anti-cancer activity[1]. | [References]
[1] Taniguchi T, et al. Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity. ACS Med Chem Lett. 2019 Mar 15;10(5):737-742. DOI:10.1021/acsmedchemlett.8b00631 |
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