| Identification | Back Directory | [Name]
L-Tryptophan, glycyl-L-tryptophyl-L-α-glutamyl-L-alanyl-L-leucyl-L-lysyl-L-tyrosyl-L-leucyl-L-tryptophyl-L-asparaginyl-L-leucyl-L-leucyl-L-glutaminyl-L-tyrosyl- | [CAS]
2305092-66-2 | [Synonyms]
L-Tryptophan, glycyl-L-tryptophyl-L-α-glutamyl-L-alanyl-L-leucyl-L-lysyl-L-tyrosyl-L-leucyl-L-tryptophyl-L-asparaginyl-L-leucyl-L-leucyl-L-glutaminyl-L-tyrosyl- | [Molecular Formula]
C100H135N21O22 | [MOL File]
2305092-66-2.mol | [Molecular Weight]
1983.27 |
| Chemical Properties | Back Directory | [Boiling point ]
2157.3±65.0 °C(predicted) | [density ]
1.312±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
3.35±0.10(predicted) | [Sequence]
Gly-Trp-Glu-Ala-Leu-Lys-Tyr-Leu-Trp-Asn-Leu-Leu-Gln-Tyr-Trp |
| Hazard Information | Back Directory | [Uses]
F9170 is an amphipathic peptide with an activity of inactivate HIV-1 virions. F9170 targets the conserved cytoplasmic tail of HIV-1 env and disrupts the integrity of the viral membrane. F9170 is able to cross the blood-brain barrier (BBB)[1]. | [References]
[1] Qian Wang, et al. An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells. Sci Transl Med. 2020, 12, 546. DOI:10.1126/scitranslmed.aaz2254 |
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