2306481-24-1

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2306481-24-1 Structure

Identification	Back Directory
[Name] INDEX NAME NOT YET ASSIGNED
[CAS] 2306481-24-1
[Synonyms]
[Molecular Formula] C127H216N54O29S3
[MOL File] 2306481-24-1.mol
[Molecular Weight] 3059.62

Chemical Properties	Back Directory
[density ] 1.58±0.1 g/cm3(Predicted)
[storage temp. ] -20°C
[form ] film
[color ] white to off-white

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[Biological Activity]

CIGB-300 (P15-Tat) is a substrate-competitive casein kinase 2 inhibitor (CK2CKII) composed of a membrane-permeant HIV-1 T at protein transduction domain sequence (a.a. 48-60) N-terminal to a disulfide-bridged cyclic substrate peptide th at inhibits against CK2-mediated substrate HPV-16 E7 phosphorylation in vitro. CIGB-300 exhibits cytotoxic effect in various cancer cultures (IC50 from 20 to 182 μM) via apoptosis induction and effectively inhibits TC-1 tumor growth in mice in vivo (48 μmol/200 μL/mouse via daily intratumoral injection).

2306481-24-1 suppliers list

Company Name:	Merck KGaA
Tel:	21-20338288
Website:	www.sigmaaldrich.cn

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2306481-24-1

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