| Chemical Properties | Back Directory | [Boiling point ]
922.619±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.261±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
13.481±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
TDI-8304, a macrocyclic peptide, is a potent, species selective, and noncovalent Plasmodium falciparum (Pf20S) inhibitor. TDI-8304 shows highly selective for Pf20S over human proteasomes[1]. | [References]
[1] Hao-Chi Hsu, et al. Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nat Commun. 2023 Dec 14;14(1):8302. DOI:10.1038/s41467-023-44077-2 |
|
|