| Identification | Back Directory | [Name]
Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- | [CAS]
2307472-03-1 | [Synonyms]
Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- | [Molecular Formula]
C20H23N3O2 | [MDL Number]
MFCD34469381 | [MOL File]
2307472-03-1.mol | [Molecular Weight]
337.42 |
| Chemical Properties | Back Directory | [Boiling point ]
566.4±50.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.80±0.20(Predicted) | [color ]
Light brown to khaki |
| Hazard Information | Back Directory | [Biological Activity]
IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM.
IU1-248 exhibits an IC50 value of 0.83 μM toward USP14, which is comparable to that of IU1-47 (IC50=0.68 μM) and 10-fold more potent than that of IU1 (IC50=12.25 μM)[1]. | [References]
[1]. Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28(12):1186-1194. |
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