| Identification | Back Directory | [Name]
girinimbine | [CAS]
23095-44-5 | [Synonyms]
girinimbine
3,11-Dihydro-3,3,5-trimethylpyrano[3,2-a]carbazole
Pyrano[3,2-a]carbazole, 3,11-dihydro-3,3,5-trimethyl- | [Molecular Formula]
C18H17NO | [MDL Number]
MFCD27967514 | [MOL File]
23095-44-5.mol | [Molecular Weight]
263.33 |
| Chemical Properties | Back Directory | [Melting point ]
176 °C | [Boiling point ]
450.0±34.0 °C(Predicted) | [density ]
1.187±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
17.31±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Girinimbine is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis and has antibacterial, anti-inflammatory, antioxidant and antitumor activities. | [Definition]
ChEBI: A natural product found in Clausena harmandiana. | [in vivo]
Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid[2].
In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos[2]. | Animal Model: | Male ICR mice (25-35 g) treated with carrageenan[2] | | Dosage: | 10 mg/kg, 30 mg/kg, and 100 mg/kg
| | Administration: | Orally gavage; once | | Result: | Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid.
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