| Identification | Back Directory | [Name]
LMPTP INHIBITOR 1 dihydrochloride | [CAS]
2310135-46-5 | [Synonyms]
LMPTP INHIBITOR 1 dihydrochloride
inhibit,LMPTP inhibitor-1,LMPTP inhibitor 1,LMPTP INHIBITOR 1 dihydrochloride,Phosphatase,LMPTP inhibitor1,Inhibitor | [Molecular Formula]
C28H37ClN4O | [MDL Number]
MFCD31807303 | [MOL File]
2310135-46-5.mol | [Molecular Weight]
481.08 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20mg/mL; DMSO: 10mg/mL; Ethanol: 15mg/mL; PBS (pH 7.2): 3mg/mL | [form ]
A crystalline solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. | [in vivo]
LMPTP inhibitor 1 is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight[1]. | [storage]
Store at -20°C | [References]
[1] Stanford SM1, et al. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 Jun;13(6):624-632. DOI:10.1038/nchembio.2344 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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