| Identification | Back Directory | [Name]
4H-Pyrrolo[2,3-d]thiazole-5-carboxamide, N-[[2-(2-benzofuranyl)phenyl]methyl]- | [CAS]
2310293-81-1 | [Synonyms]
4H-Pyrrolo[2,3-d]thiazole-5-carboxamide, N-[[2-(2-benzofuranyl)phenyl]methyl]- | [Molecular Formula]
C21H15N3O2S | [MOL File]
2310293-81-1.mol | [Molecular Weight]
373.43 |
| Hazard Information | Back Directory | [Uses]
Microtubule inhibitor 8 (MP-HJ-1b) is a potent inhibitor of microtubule. Microtubule inhibitor 8 triggers cell death through ferroptosis. Microtubule inhibitor 8 has anti-tumor effect[1][2]. | [References]
[1] Nannan Ning, et al. A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors. Cancer Res. 2018 Oct 15;78(20):5949-5957. DOI:10.1158/0008-5472.CAN-18-0455
[2] Nannan Ning, et al. A novel microtubule inhibitor promotes tumor ferroptosis by attenuating SLC7A11/GPX4 signaling. Cell Death Discov. 2023 Dec 13;9(1):453. DOI:10.1038/s41420-023-01713-6 |
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