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2319838-82-7

2319838-82-7 Structure

2319838-82-7 Structure
IdentificationBack Directory
[Name]

AGN 193109 (sodium salt)
[CAS]

2319838-82-7
[Synonyms]

4-[2-[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]-benzoicacid,monosodiumsalt
[Molecular Formula]

C28H25NaO2
[MOL File]

2319838-82-7.mol
[Molecular Weight]

416.5
Chemical PropertiesBack Directory
[solubility ]

DMSO: Slightly Soluble
Methanol: Slightly Soluble
Hazard InformationBack Directory
[Uses]

AGN 193109 sodium is the sodium salt form of AGN 193109 (HY-U00449). AGN 193109 sodium is the pan antagonist for retinoic acid receptor (RAR), with Kd of 2, 2 and 3 nM, for RARα, RARβ and RARγ, respectively. AGN 193109 sodium reverses TTNPB-induced morphology changes and all-trans retinoic acid (tRA)/9-cis RA/13-cis RA-induced proliferation suppression in ECE16-1 cell. AGN 193109 sodium is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity[1][2].
[IC 50]

RXR α: 2 nM (Kd); RXR β: 2 nM (Kd); RXR γ: 2 nM (Kd)
[References]

[1] Standeven AM, et al. Specific antagonist of retinoid toxicity in mice. Toxicol Appl Pharmacol. 1996 May;138(1):169-75. DOI:10.1006/taap.1996.0110
[2] Agarwal C, et al. AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J Biol Chem. 1996 May 24;271(21):12209-12. DOI:10.1074/jbc.271.21.12209
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