| Identification | Back Directory | [Name]
ML218 hydrochloride | [CAS]
2319922-08-0 | [Synonyms]
ML218 hydrochloride,ML-218 hydrochloride | [Molecular Formula]
C19H27Cl3N2O | [MDL Number]
MFCD22683841 | [MOL File]
2319922-08-0.mol | [Molecular Weight]
405.79 |
| Hazard Information | Back Directory | [Biological Activity]
ML 218 hydrochloride is a selective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, Kir6 (KATP) or KV11.1 (hERG) potassium channels. ML 218 hydrochloride inhibits oral cancer cell proliferation. Orally active. | [storage]
Store at +4°C |
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