| Identification | Back Directory | [Name]
3-Bromotyrosine (trifluoroacetate salt) | [CAS]
2320428-62-2 | [Synonyms]
3-Bromotyrosine (trifluoroacetate salt) | [Molecular Formula]
C11H11BrF3NO5 | [MOL File]
2320428-62-2.mol | [Molecular Weight]
374.108 |
| Hazard Information | Back Directory | [Description]
3-Bromotyrosine is a product of protein oxidation found after activation of eosinophils during an allergic response.1,2,3 It has been used as a marker of eosinophil peroxidase-induced protein oxidation in vitro and in vivo.2,4 In addition to its production in eosinophils, 3-bromotyrosine is found at 5-fold higher levels in peritoneal exudate from mice infected with K. pneumoniae compared with uninfected animals, suggesting neutrophils release higher levels of oxidized products during inflammation.5 In a human study, 3-bromotyrosine was increased 10-fold in allergen-challenged lung samples from subjects with allergen-induced asthma.2 | [References]
1. Mennini, T., Bizzi, A., Caccia, S., et al. Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigs Naunyn-Schmiedeberg's Arch. Pharmacol. 343(5),483-490(1991).
2. Heinecke, J.W. Eosinophil-dependent bromination in the pathogenesis of asthma J. Clin. Invest. 105(10),1331-1332(2000).
3. Chen, H.-J., and Chiu, W.-L. Simultaneous detection and quantification of 3-nitrotyrosine and 3-bromotyrosine in human urine by stable isotope dilution liquid chromatography tandem mass spectrometry Toxicol. Lett. 181(1),31-39(2008).
4. MacPherson, J.C., Comhair, S.A., Erzurum, S.C., et al. Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species J. Immunol. 166(9),5763-5772(2001).
5. Wu, W., Chen, Y., d'Avignon, A., et al. 3-Bromotyrosine and 3,5-dibromotyrosine are major products of protein oxidation by eosinophil peroxidase: Potential markers for eosinophil-dependent tissue injury in vivo Biochemistry 38(12),3538-3548(1999). |
|
|