| Identification | Back Directory | [Name]
Nw-Propyl-L-arginine hydrochloride | [CAS]
2321366-46-3 | [Synonyms]
Nw-Propyl-L-arginine hydrochloride | [Molecular Formula]
C9H21ClN4O2 | [MDL Number]
MFCD18086926 | [MOL File]
2321366-46-3.mol | [Molecular Weight]
252.74 |
| Hazard Information | Back Directory | [Uses]
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS)[1][2]. | [in vivo]
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride (20 mg/kg; i.p.) blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity[2]. | Animal Model: | Male NMRI mice (30-40 g) (phencyclidine-induced stimulation)[2] | | Dosage: | 20 mg/kg | | Administration: | I.p. | | Result: | Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity.
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| [storage]
Store at -20°C | [References]
[1] Zhang HQ, et al. Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. J Med Chem. 1997 Nov 21;40(24):3869-70. DOI:10.1021/jm970550g
[2] Klamer D, et al. The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. Eur J Pharmacol. 2004 Oct 25;503(1-3):103-7. DOI:10.1016/j.ejphar.2004.09.042 |
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