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2321366-46-3

2321366-46-3 Structure

2321366-46-3 Structure
IdentificationBack Directory
[Name]

Nw-Propyl-L-arginine hydrochloride
[CAS]

2321366-46-3
[Synonyms]

Nw-Propyl-L-arginine hydrochloride
[Molecular Formula]

C9H21ClN4O2
[MDL Number]

MFCD18086926
[MOL File]

2321366-46-3.mol
[Molecular Weight]

252.74
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Oil
[color ]

Colorless to off-white
Hazard InformationBack Directory
[Uses]

Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS)[1][2].
[in vivo]

Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride (20 mg/kg; i.p.) blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity[2].

Animal Model:Male NMRI mice (30-40 g) (phencyclidine-induced stimulation)[2]
Dosage:20 mg/kg
Administration:I.p.
Result:Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity.
[storage]

Store at -20°C
[References]

[1] Zhang HQ, et al. Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. J Med Chem. 1997 Nov 21;40(24):3869-70. DOI:10.1021/jm970550g
[2] Klamer D, et al. The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. Eur J Pharmacol. 2004 Oct 25;503(1-3):103-7. DOI:10.1016/j.ejphar.2004.09.042
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