| Identification | Back Directory | [Name]
FAUC73 | [CAS]
23255-54-1 | [Synonyms]
b-idroeritroidina
Dihydro-b-erythroidine
Dihydro-β-erythroidine
dihydro-beta-erythroidin
dihydro-beta-erythroidine
1,6-didehydro-14,17-dihydro-3-methoxy-16(5h)-oxaerythrinan-15-on(3-beta) | [Molecular Formula]
C16H21N1O3 | [MOL File]
23255-54-1.mol | [Molecular Weight]
205.34 |
| Hazard Information | Back Directory | [Uses]
Dihydro-β-erythroidine is a a competitive nicotinic receptor antagonist. Dihydro-β-erythroidine blocks the discriminative stimulus properties of nicotine. Dihydro-β-erythroidine inhibits the anxiolytic effect of nicotine induced[1][2]. | [Definition]
ChEBI: An organic heterotetracyclic compound resulting from the partial hydrogenation of the 1,3-diene moiety of beta-erythroidine to give the corresponding 2-ene. | [in vivo]
Dihydro-β-erythroidine (0.5, 1.6, 5.0 mg/kg; s.c.) blocks the discriminative stimulus properties of nicotine in rats[1].
Dihydro-β-erythroidine (100 ng) shows antagonism of the anxiolytic effect of nicotine in the dorsal raphe′ nucleus in rats[2]. | Animal Model: | 200-250 g male hooded Lister rats[1] | | Dosage: | 0.5, 1.6, 5.0 mg/kg | | Administration: | S.c. | | Result: | Prevented the development of CTAs (conditioned taste aversion) and blocked the discriminative stimulus effect of nicotine (0.2 or 0.4 mg/kg SC) for 45 min after its administration. |
| [References]
[1] Shoaib M, et al. Antagonism of stimulus properties of nicotine by dihydro-beta-erythroidine (DHbetaE) in rats. Psychopharmacology (Berl). 2000 Apr;149(2):140-6. DOI:10.1007/s002139900348
[2] Cheeta S, et al. Antagonism of the anxiolytic effect of nicotine in the dorsal raphe nucleus by dihydro-beta-erythroidine. Pharmacol Biochem Behav. 2001 Dec;70(4):491-6. DOI:10.1016/s0091-3057(01)00641-4 |
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