| Chemical Properties | Back Directory | [Boiling point ]
40.5-44.0 °C(Press: 12 Torr) | [density ]
1.58 g/cm3(Temp: 25 °C) | [solubility ]
sol diethyl ether, trifluoroacetic acid, carbon tetrachloride | [pka]
-3.57±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
4-chloromorpholine is a useful reagent for selective and efficient chlorination of activated aromatics.
| [Synthesis Reference(s)]
1. Smith, J. R. L.; McKeer, L. C.; Taylor, J. M. OSC 1993, 8, 167.
2. Smith, J. R. L.; McKeer, L. C.; Taylor, J. M. JCS(P2) 1987, 1533.
| [Synthesis]
4-chloromorpholine is synthesized by Morpholine and aqueous Sodium Hypochlorite at <10 °C, followed by ether extraction, concentration below 30 °C, and vacuum distillation.1,2
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