| Identification | Back Directory | [Name]
Chlorflavonin | [CAS]
23363-64-6 | [Synonyms]
Chlorflavonin
Chlorflavonin >=98% (HPLC)
3'-Chloro-2',5-dihydroxy-3,7,8-trimethoxyflavone
2-(3-Chloro-2-hydroxyphenyl)-5-hydroxy-3,7,8-trimethoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(3-chloro-2-hydroxyphenyl)-5-hydroxy-3,7,8-trimethoxy- | [Molecular Formula]
C18H15ClO7 | [MDL Number]
MFCD32174337 | [MOL File]
23363-64-6.mol | [Molecular Weight]
378.76 |
| Chemical Properties | Back Directory | [Boiling point ]
612.7±55.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
6.61±0.40(Predicted) | [color ]
white to beige | [InChI]
1S/C18H15ClO7/c1-23-11-7-10(20)12-14(22)18(25-3)15(26-17(12)16(11)24-2)8-5-4-6-9(19)13(8)21/h4-7,20-21H,1-3H3 | [InChIKey]
JLSQXYITDXJTKL-UHFFFAOYSA-N | [SMILES]
OC1=CC(OC)=C(C2=C1C(C(OC)=C(C3=C(O)C(Cl)=CC=C3)O2)=O)OC |
| Hazard Information | Back Directory | [Definition]
ChEBI: A dihydroxyflavone that is flavone substituted by a chloro group at position 3', hydroxy groups at positions 5 and 2' and methoxy groups at positions 3, 7 band 8 respectively. | [Biological Activity]
Originally isolated from Aspergillus candidus LinkChlorflavonin is a non-cytotoxic (up to 100 μM; MRC-5 and THP-1) antibiotic with antifungal activity against certain species of mold fungi (MIC = 0.08 μg/mL against A. amstelodamiA. fumigalusA. ochraceous; Paecilomyces variotii MIC = 2.5 μg/mLBotrytis cinerea MIC = 5 μg/mL). Chlorflavonin also exhibits antibiotic activity against M. tuberculosis (MIC90 = 1.56 μM) by targeting acetohydroxyacid synthase (AHAS) catalytic subunit ilvB1. Chlorflavonin is superior to streptomycin against M. tuberculosis inside infected macrophagessynergizes with isoniazid and delamanidleading to a complete sterilization in liquid cultures. |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
CHEMICAL LAND21
|
| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
|