| Identification | Back Directory | [Name]
1,4-Butanediamine, N1-[2-[(1E)-2-(4-nitrophenyl)ethenyl]-4-quinazolinyl]- | [CAS]
2338764-89-7 | [Synonyms]
p53 Activator 2
1,4-Butanediamine, N1-[2-[(1E)-2-(4-nitrophenyl)ethenyl]-4-quinazolinyl]- | [Molecular Formula]
C20H21N5O2 | [MOL File]
2338764-89-7.mol | [Molecular Weight]
363.41 |
| Hazard Information | Back Directory | [Uses]
p53 Activator 2 (compound 10ah) intercalats into DNA and results in significant DNA double-strand break.p53 Activator 2 increases the expression of p53, p-p53, CDK4, p21 to cause cell cycle arrest at G2/M phase.p53 Activator 2 induce apoptosis and significantly down-regulates the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1.p53 Activator 2 has anti-proliferation activity against MGC-803 cells, with an IC50 of 1.73 μM. p53 Activator 2 displays potent anticancer efficiency against MGC-803 xenograft tumors models[1]. | [References]
[1] Xin-Wei Wei?, et al. 2-Styryl-4-aminoquinazoline derivatives as potent DNA-cleavage, p53-activation and in vivo effective anticancer agents. Eur J Med Chem. 2020 Jan 15;186:111851. DOI:10.1016/j.ejmech.2019.111851 |
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