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2349392-79-4

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2349392-79-4 Structure

2349392-79-4 Structure
IdentificationBack Directory
[Name]

KRAS G12C inhibitor 16
[CAS]

2349392-79-4
[Synonyms]

KRAS G12C inhibitor 16
KRAS G-12C inhibitor 16,KRAS G12C inhibitor 16
2-Propen-1-one, 1-[(4aR)-11-chloro-10-(2-fluoro-6-hydroxyphenyl)-1,2,4a,5-tetrahydro-9-methylpyrazino[1',2':4,5][1,4]oxazino[2,3-c]quinolin-3(4H)-yl]-
[Molecular Formula]

C24H21ClFN3O3
[MDL Number]

MFCD32201077
[MOL File]

2349392-79-4.mol
[Molecular Weight]

453.89
Hazard InformationBack Directory
[Uses]

KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 39, has an IC50 of 97 nM[1].
[IC 50]

KRas G12C: 97 nM (IC50)
[References]

[1] Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents. WO2019110751A1.
Spectrum DetailBack Directory
[Spectrum Detail]

KRAS G12C inhibitor 16(2349392-79-4)1HNMR
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