| Identification | Back Directory | [Name]
1-Piperidineacetamide, N-(4-chlorophenyl)-4-(6-fluoro-4-quinolinyl)-3-hydroxy-α-oxo-, (3R,4R)- | [CAS]
2351199-98-7 | [Synonyms]
IDO1-IN-7
1-Piperidineacetamide, N-(4-chlorophenyl)-4-(6-fluoro-4-quinolinyl)-3-hydroxy-α-oxo-, (3R,4R)- | [Molecular Formula]
C22H19ClFN3O3 | [MOL File]
2351199-98-7.mol | [Molecular Weight]
427.86 |
| Hazard Information | Back Directory | [Uses]
IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC50 of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer[1]. | [in vivo]
IDO1-IN-7 (10 mg/kg; p.o.) shows Cmax=10.0 μM, AUC0-8 h=27.1 μM*h, t1/2=1.4 h in mouse[1].
| Animal Model: | Mouse[1] | | Dosage: | 10 mg/kg (Pharmacokinetic Analysis) | | Administration: | Oral administration | | Result: | Cmax (10.0 μM), AUC0-8 h (27.1 μM*h), t1/2 (1.4 h) |
| [References]
[1] Christoph Steeneck, et al. Discovery and optimization of substituted oxalamides as novel heme-displacing IDO1 inhibitors. Bioorg Med Chem Lett. 2020 Dec 15;33:127744. DOI:10.1016/j.bmcl.2020.127744 |
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