| Identification | Back Directory | [Name]
N-(DBCO-PEG4)-N-Biotin-PEG4-NHS | [CAS]
2353409-72-8 | [Synonyms]
N-(DBCO-PEG4)-N-Biotin-PEG4-NHS
4,7,10,13,19,22,25,28-Octaoxa-16,31-diazapentatriacontanoic acid, 35-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-16-[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]-32,35-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C54H74N6O16S | [MDL Number]
MFCD31811479 | [MOL File]
2353409-72-8.mol | [Molecular Weight]
1095.26 |
| Hazard Information | Back Directory | [Description]
N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a click chemistry biotinylation reagent, NHS active esters can be used to label the primary amines (-NH2) of proteins and other amine-attached macromolecule. DBCO group is very reactive with azide molecule via copper-free Click Chemistry. | [Uses]
N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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