2353409-81-9

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2353409-81-9 Structure

Chemical Properties	Back Directory
[Boiling point ] 829.0±65.0 °C(Predicted)
[density ] 1.20±0.1 g/cm3(Predicted)
[solubility ] Soluble in DMSO, DCM, DMF
[form ] Oil
[pka] 11.95±0.46(Predicted)
[color ] Off-white to light yellow

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H315-H319-H335
[Precautionary statements ] P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Hazard Information	Back Directory
[Description] Gly-Gly-Gly-PEG3-TCO is a cleavable PEG linker used in the synthesis of antibody-drug conjugates.
[Uses] Gly-Gly-Gly-PEG3-TCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50] Cleavable Linker
[References] [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

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