| Identification | Back Directory | [Name]
t-Boc-Aminooxy-PEG8-alcohol | [CAS]
2353410-14-5 | [Synonyms]
Boc-Aminooxy-PEG8
t-Boc-Aminooxy-PEG8-alcohol | [Molecular Formula]
C21H43NO11 | [MDL Number]
MFCD31693705 | [MOL File]
2353410-14-5.mol | [Molecular Weight]
485.57 |
| Hazard Information | Back Directory | [Description]
t-Boc-Aminooxy-PEG8-alcohol is an aqueous soluble reagent comprising a Boc-protected aminooxy group and an alcohol group. The protected aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde group to form a stable oxime linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | [Uses]
t-Boc-Aminooxy-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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