2353410-14-5

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2353410-14-5 Structure

Identification	Back Directory
[Name] t-Boc-Aminooxy-PEG8-alcohol
[CAS] 2353410-14-5
[Synonyms] Boc-Aminooxy-PEG8 t-Boc-Aminooxy-PEG8-alcohol
[Molecular Formula] C21H43NO11
[MDL Number] MFCD31693705
[MOL File] 2353410-14-5.mol
[Molecular Weight] 485.57

Chemical Properties	Back Directory
[density ] 1.113±0.06 g/cm3(Predicted)
[solubility ] Soluble in DMSO, DCM, DMF
[pka] 14.36±0.10(Predicted)

Hazard Information	Back Directory
[Description] t-Boc-Aminooxy-PEG8-alcohol is an aqueous soluble reagent comprising a Boc-protected aminooxy group and an alcohol group. The protected aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde group to form a stable oxime linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
[Uses] t-Boc-Aminooxy-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50] PEGs; Alkyl/ether
[References] [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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