| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)- | [CAS]
2357110-14-4 | [Synonyms]
Thalidomide-Piperazine-PEG2-NH2
5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione,
1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)- | [Molecular Formula]
C23H31N5O6 | [MOL File]
2357110-14-4.mol | [Molecular Weight]
473.52 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-Piperazine-PEG2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | [IC 50]
Cereblon | [References]
[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-999. DOI:10.1016/j.str.2020.07.013 |
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