2357117-23-6

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2357117-23-6 Structure

Identification	Back Directory
[Name] 4-((17-amino-3,6,9,12,15-pentaoxaheptadecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
[CAS] 2357117-23-6
[Synonyms] Pomalidomide-NH-PEG5-amine hydrochlorid Thalidomide-NH-PEG5-C2-NH2 hydrochloride Pomalidomide-NH-PEG5-amine hydrochloride 4-((17-amino-3,6,9,12,15-pentaoxaheptadecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
[MDL Number] MFCD32903279
[MOL File] 2357117-23-6.mol
[Molecular Weight] 573.04

Chemical Properties	Back Directory
[solubility ] Methanol: Sparingly soluble: 1-10 mg/ml
[form ] Solid
[color ] Light yellow to yellow

Hazard Information	Back Directory
[Uses] Pomalidomide-PEG5-C2-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-PEG5-C2-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1].
[References] [1] IVÁN CHENG-SÁNCHEZ, CRISTINA NEVADO* Discovery and Characterization of Active CBP/EP300 Degraders Targeting the HAT Domain[J]. ACS Medicinal Chemistry Letters, 2024, 15 3: 355-361. DOI: 10.1021/acsmedchemlett.3c00490 [2] SHULEI ZHU . Design, synthesis, and biological evaluation of Wee1 kinase degraders[J]. European Journal of Medicinal Chemistry, 2022, 243: Article 114786. DOI: 10.1016/j.ejmech.2022.114786

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