| Identification | Back Directory | [Name]
8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE | [CAS]
23583-48-4 | [Synonyms]
B-cAMP
8-BR-CAMP
8-BROMO-CAMP
8-Br-A-3:5-MP
8-BR-CAMP,98+%
8-Bromocyclic AMP
Cyclic amp, 8-bromo
-CyclicMonophosphate
8-bromo-3',5'-cyclic AMP
8-Bromo-cyclic 3',5'-amp
8-BROMOADENOSINE 3' 5'-CYCLIC
8-Bromoadenosine 3',5'-monophosphate
8-BROMOADENOSINE-3',5'-CYCLOPHOSPHATE
8-Bromo Cyclic Adenosine Monophosphate
8-Bromoadenosine 3',5'-phosphoric acid
8-Bromoadenosine cyclic 3',5'-phosphate
Cyclic 8-bromoadenosine 3',5'-monophosphate
8-BROMOADENOSINE-3',5'-CYCLOPHOSPHORIC ACID
8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE
8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE
8-BROMO-ADENOSINE CYCLIC 3',5'-HYDROGEN PHOSPHATE
8-BROMOADENOSINE-3-5-CYCLICMONOPHOSPHATE FREE ACID
8-Bromoadenosine-3'',-5''-cyclic monophosphoric acid
8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE USP/EP/BP
Adenosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate) | [EINECS(EC#)]
245-760-6 | [Molecular Formula]
C10H11BrN5O6P | [MDL Number]
MFCD00075580 | [MOL File]
23583-48-4.mol | [Molecular Weight]
408.1 |
| Chemical Properties | Back Directory | [Melting point ]
254 °C (dec.) (lit.) | [Boiling point ]
741.9±70.0 °C(Predicted) | [density ]
2.80±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
aqueous base: soluble | [form ]
Powder | [pka]
0.95±0.60(Predicted) | [color ]
Pale Brown | [Sensitive ]
Hygroscopic | [BRN ]
591930 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
8-Bromoadenosine 3′,5′-cyclic monophosphate has been used:
- to treat H295R cells as positive controls for CYP19 induction
- as a membrane permeable cAMP analog to study its effect on short-circuit current (Isc)
- to investigate its potential as an inducer of differentiation in Wharton′s jelly-derived mesenchymal stem cells (WJ-MSCs)
| [Definition]
ChEBI: A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP bearing an additional bromo substituent at position 8 on the adenine ring. An activator of cyclic AMP-dependent protein kinase. | [Biochem/physiol Actions]
8-bromo-adenosine?3′,5′-cyclic?monophosphate?(8-bromo-cAMP), added to hepatocytes during plating helps to increase the acquisition of beta-adrenoceptors. | [in vivo]
8-Bromo-cAMP (60 mg/kg/day, i.p., 7 days) reduces tumor in CT26 tumor mice[4].
| Animal Model: | CT26 tumor mice[4] | | Dosage: | 60 mg/kg/day | | Administration: | i.p., 7 days | | Result: | Decreases amounts of primary CRC tumor nodules and liver metastases.
Reduces vasculogenic mimicry (PAS–CD31 staining of colorectal and intestinal tumors).
Inhibits cAMP and VEGF expression, increases expression of PKA in tumor tissues.
|
| [storage]
Store at -20°C |
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