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2358754-22-8

2358754-22-8 Structure

2358754-22-8 Structure
IdentificationBack Directory
[Name]

LH2-051
[CAS]

2358754-22-8
[Synonyms]

LH2-051
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Off-white to light brown
Hazard InformationBack Directory
[Uses]

LH2-051 is a lysosome-enhancing lead compound, which promotes the lysosome biogenesis and the Aβ aggregate clearance through dopamine transporter-cyclin-dependent kinase 9-transcription factor EB (DAT-CDK9-TFEB) pathway. LH2-051 exhibits good pharmacokinetic characteristics in mouse models. LH2-051 is potential for ameliorating Aleheimer’s Disease[1].
[References]

[1] Zhou J, et al., Discovery and Optimization of Tetrahydroisoquinoline Derivatives To Enhance Lysosome Biogenesis as Preclinical Candidates for the Treatment of Alzheimer's Disease. J Med Chem. 2024 Jun 13;67(11):8836-8861. DOI:10.1021/acs.jmedchem.4c00159
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