| Identification | Back Directory | [Name]
PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-ARG-LYS-ASN-GLN | [CAS]
236098-40-1 | [Synonyms]
[ARG14,LYS15]NOCICEPTIN
[ARG14,LYS15] ORPHANIN FQ
[ARG14, LYS15]NOCICEPTIN/ORPHANIN FQ
PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-ARG-LYS-ASN-GLN
L-Glutamine, L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-arginyl-L-lysyl-L-asparaginyl- | [Molecular Formula]
C82H137N31O22 | [MDL Number]
MFCD03791320 | [MOL File]
236098-40-1.mol | [Molecular Weight]
1909.16 |
| Hazard Information | Back Directory | [Uses]
[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively[1]. | [in vivo]
In in vivo experiments, [Arg14,Lys15]Nociceptin mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice[2]. | [storage]
Desiccate at -20°C | [References]
[1] Okada K, Sujaku T, Chuman Y, et al. Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem Biophys Res Commun. 2000;278(2):493-498. DOI:10.1006/bbrc.2000.3822
[2] Rizzi D, Rizzi A, Bigoni R, et al. [Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J Pharmacol Exp Ther. 2002;300(1):57-63. DOI:10.1124/jpet.300.1.57 |
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