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2361142-23-4

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2361142-23-4 Structure

2361142-23-4 Structure
IdentificationBack Directory
[Name]

CCW 28-3
[CAS]

2361142-23-4
[Synonyms]

CCW 28-3
Hazard InformationBack Directory
[Uses]

CCW 28-3 is a PROTAC-based BRD4 degrader in a proteasome- and RNF4-dependent manner (Pink: JQ-1 (carboxylic acid) (HY-78695); Black: linker (HY-170384); Blue: RNF4 ligand CCW16 (HY-143346))[1].
[References]

[1] Carl C Ward, et al. Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. DOI:10.1021/acschembio.8b01083
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