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D-F07 is a prodrug with an aldehyde shielding group and an IRE-1 inhibitor that induces Apoptosis. D-F07 has antitumor activity[1][2]. | [References]
[1] Shao A, et al. Development of Tumor-Targeting IRE-1 Inhibitors for B-cell Cancer Therapy. Mol Cancer Ther. 2020 Dec;19(12):2432-2444. DOI:10.1158/1535-7163.MCT-20-0127
[2] Shao A, et al. IRE-1-Targeting Caged Prodrug with Endoplasmic Reticulum Stress-Inducing and XBP-1S-Inhibiting Activities for Cancer Therapy. Mol Pharm. 2022 Apr 4;19(4):1059-1067. DOI:10.1021/acs.molpharmaceut.1c00639 |
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