236406-22-7

530115-96-9

236406-22-7

General procedure for the synthesis of tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate from tert-butyl 4-cyano-4-methylpiperidine-1-carboxylate: Compound 25 (1.00 g, 4.46 mmol) was reacted with Rh/Al2O3 catalyst (300 mg, 5 wt%, 0.14 mmol) in a methanol-ammonia solution under hydrogen atmosphere (40 psi) ( 15 mL, 3.5 N NH3 in MeOH) was subjected to a shaking reaction. After completion of the reaction, the reaction mixture was filtered through a silica gel pad and the filtrate was concentrated to give the target product compound 26 (1.00 g, 98% yield).