2364489-81-4

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2364489-81-4 Structure

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[Uses] FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively[1].
[Biological Activity] FMF-04-159-2 is a specific and potent covalent inhibitor Cyclin-dependent kinase 14 (CDK14) in cells th at targets CDK14 at C218. FMF-04-159-2 reversibly inhibits CDK2CDK10and other TAIRE kinases (CDK15CDK16CDK17and CDK18) with comparable potency to each other. It exhibits mild antiproliferative effects.
[IC 50] CDK14/Cyclin Y: 39.6 nM (IC₅₀, in NanoBRET assay); CDK2: 256 nM (IC₅₀, in NanoBRET assay)
[storage] Store at -20°C
[References] [1] Ferguson FM, et al. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019 Mar 11. pii: S2451-9456(19)30070-4. DOI:10.1016/j.chembiol.2019.02.015

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[Spectrum Detail] FMF-04-159-2(2364489-81-4)¹HNMR

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